60th Anniversary of the European Journal of Histochemistry, founded in 1954 as "Rivista di Istochimica Normale e Patologica" - Reprint of Vol. 1, no. 1 - Introduction, together with a commending letter of the Editors
Cerebellar abnormalities in prolidase deficient mice. In the cerebellum of wild type mice (left panel), laminin immunopositivity (green fluorescence) shows the basal lamina as a continuous layer, whereas in prolidase deficient mice (right panel), cortical abnormality are found with lack of the basal lamina. GFAP immunopositive fibers and their endfeet reach the cerebellar surface in wild type mice (red fluorescence in the inset of the left panel), but in prolidase deficient mice (inset, right) they are disorganized and their endfeet cannot be observed. The blue fluorescence is for DNA staining with Hoechst 33258. Courtesy of V. Insolia and V.M. Piccolini ("Brain morphological defects in prolidase deficient mice: first report", in publication).